Permethrin-treated clothing is the CDC and military recommended approach for tick and mosquito protection in the field. Unlike skin repellents that wear off in hours, permethrin bonds to fabric fibers and remains effective through 6 washes (spray) or 70 washes (factory-treated). It kills ticks on contact within 30 seconds.
Ticks (kills on contact in 30-60 seconds - the gold standard for Lyme prevention), mosquitoes (kills and repels), chiggers, mites, biting flies, fleas. The US military has treated uniforms with permethrin since the 1990s for protection against disease-vectoring arthropods in the field.
Sawyer Permethrin Spray (0.5% - the most popular DIY product), Repel Permanone, Ben permethrin spray, Insect Shield (factory-treated clothing - lasts 70 washes), ExOfficio BugsAway clothing line, LL Bean No Fly Zone clothing, REI Co-op permethrin-treated gear. US military ACUs are factory-treated.
Permethrin is safe on clothing but should NOT be applied to skin (unlike DEET). Once dried on fabric (2-4 hours), it is not absorbed through skin in any meaningful amount. The EPA has concluded that wearing permethrin-treated clothing poses negligible risk to human health.
How to treat clothing: Lay garments flat outdoors on a surface you do not mind getting sprayed. Spray Sawyer Permethrin evenly on both sides until lightly damp (not soaking). Treat: pants, socks, shoes, shirt, hat, and backpack. Let dry completely (2-4 hours). Wear normally. Effective through 6 washes or 42 days of sun exposure.
What to treat: Focus on the items ticks contact first: socks, shoes/boots, pant legs, and gaiters. These are the front line of defense. Also treat shirts, hats, and backpacks for mosquito protection.
Factory-treated vs DIY spray: Factory-treated clothing (Insect Shield, ExOfficio BugsAway) lasts 70+ washes and is more evenly distributed. DIY spray (Sawyer) lasts 6 washes but costs less and lets you treat any garment. Both are highly effective.
The 30-second tick kill: In lab studies, ticks placed on permethrin-treated fabric become disoriented within seconds and die within 30-60 seconds. They literally cannot survive contact with properly treated clothing. This is why the military has mandated permethrin treatment for decades.