Permethrin

Active Ingredient Profile
Permethrin
Synthetic Pyrethroid · Type I · OTC Available · #1 Tick Prevention Tool
The same chemical class as bifenthrin but with a different profile — permethrin's greatest strength is fabric binding. Treated clothing kills ticks on contact and survives 6+ wash cycles. It is also the standard yard spray for mosquito and tick perimeter control. Critical warning: acutely toxic to cats — never allow cats near wet permethrin.
Clothing Residual6+ wash cycles
Yard Residual2–6 weeks
OTC Available?Yes — widely
Cat Safe?No — toxic when wet
Technical Specifications
Chemical ClassPyrethroid (Type I)
CAS Number52645-53-1
Mode of ActionSodium channel disruptor — IRAC 3A
Fabric BindingStrong — survives washing
Mammalian Tox.Very Low (dry) — LD50 >4,000 mg/kg
Cat ToxicityHigh when wet — avoid exposure
Aquatic Tox.Very High — keep from water
Organic Approved?No (synthetic)
Pyrethroid mechanism of action diagram

How pyrethroid works — illustrated mechanism of action · PestControlBasics.com

Clothing Treatment — Best Application

The #1 tick and mosquito prevention tool you're probably not using

Permethrin-treated clothing kills ticks and mosquitoes on contact — they don't need to bite through the fabric. A tick landing on a treated pant leg is dead within seconds. This is fundamentally different from repellents which just discourage landing. The effect persists through 6+ wash cycles because permethrin binds to fabric fibers.

This single habit — treating your outdoor clothing once per season — is the highest-impact personal tick prevention measure available. More effective than DEET alone. The CDC recommends it for outdoor workers, hikers, and anyone in tick-endemic areas.

1
Buy clothing spray
Sawyer Permethrin or similar 0.5% spray formulation
2
Treat outdoors
Spray clothing while hanging on a line or laying flat. Wet thoroughly. Keep pets away.
3
Dry completely
Allow 2–4 hours to dry before wearing. Odorless when dry.
4
Lasts 6+ washes
Re-treat after 6 wash cycles or at the start of each season.
👖 What to Treat

Pants, socks, shoes, shirts, hats, and gear (backpacks, tents, sleeping bags). Focus especially on socks and lower pant legs where ticks typically first contact clothing. Treat the exterior surface — not the skin-contact side.

Yard & Perimeter Treatment

Permethrin vs. bifenthrin for yard spray — when to use which

Bifenthrin (Talstar/Bifen IT)
Residual4–8 weeks
Best forAnts, perimeter, fire ants
CostLower per application
Concentration7.9% concentrate OTC
Cat safetySafe when dry
Permethrin (Martin's, Sawyer)
Residual2–6 weeks
Best forTicks, mosquitoes, clothing
CostComparable
Concentration10% concentrate OTC
Cat safetyToxic when wet

For yard tick control, apply permethrin to the lawn-woodland edge (the 9-foot transition zone between maintained grass and wooded areas) in late April and late August. Also treat along fence lines, under decks, and in tall grass areas. Do not apply to flowering plants.

Products

Permethrin products — consumer and professional

ProductConcentrationUse
Sawyer Permethrin Spray0.5%Clothing and gear treatment — #1 choice
Martin's Permethrin 10%10% concentrateDilute for yard spray — economical
Bonide Mosquito Beater0.1% RTUReady-to-use yard spray
Permanone (aerosol)0.5%Military/outdoor clothing treatment standard
Gordon's Permethrin 10%10% concentrateLivestock, dogs, yard — versatile concentrate
Safety

Critical safety information

🐱 CAT TOXICITY — Critical Warning

Permethrin is acutely toxic to cats when wet. Cats lack the liver enzyme (glucuronyl transferase) that metabolizes pyrethroids. Exposure to wet permethrin — even from treated clothing that isn't fully dry — can cause tremors, seizures, and death in cats. Always: treat clothing outdoors, dry completely before bringing inside, and keep cats away from any treated surfaces until fully dry. Dried permethrin on clothing is safe around cats.

🐡 Aquatic Toxicity

Like all pyrethroids, permethrin is highly toxic to fish and aquatic invertebrates. Never apply within 50 feet of water. Do not apply before rain. The aquatic toxicity risk is the primary environmental concern with permethrin yard applications.

🐱 Dogs and Humans — Safe When Dry

Permethrin poses very low toxicity risk to dogs and humans when dry. The EPA classifies it as likely not carcinogenic to humans. The clothing treatment use is considered one of the safest pesticide applications available — the amount absorbed through treated fabric is far below any health threshold.

📚 Sources: EPA Pesticide Labels · NPIC Pesticide Info

📋 Safety Data Sheet (SDS)

📄

Permethrin — Safety Data Sheet

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📄 Search for this SDS on CDMS →
⚖️ Educational use only. PestControlBasics.com is not a licensed pest control operator. The label is the law under FIFRA — always read and follow your product label. Full disclaimer →
Published: Jun 1, 2024 · Updated: Apr 5, 2026
🔮
Reviewed by Derek GiordanoContent on PestControlBasics.com is developed with input from certified pest management professionals and cross-referenced against EPA, CDC, and university extension guidance. Last reviewed: April 2026.
📄 Permethrin — Safety Data Sheet · View the complete SDS document above or download below
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